Bronchodilatation after inhalation of the antihistamine clemastine.
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چکیده
منابع مشابه
Bronchodilatation after inhalation of the antihistamine clemastine.
H1 receptor blocking antihistamines administered by mouth have not found a clear place in the management of bronchial asthma. We investigated the possibility that higher concentrations of these drugs, administered directly to the bronchial tree, might produce bronchodilatation. Twelve asthmatic patients inhaled aerosols generated from solutions of clemastine (0.05%), salbutamol (0.5%), and plac...
متن کاملInhaled clemastine, an H1 antihistamine inhibits airway narrowing caused by aerosols of non-isotonic saline.
Asthmatic subjects were challenged with aerosols of hyper- and hypotonic saline 15 min (Group A) and 90 min (Group B) after inhaling clemastine. Measurements were made of forced expiratory volume in one second (FEV1) before and after medication and after challenge. When the FEV1 values (% predicted) were compared on the active and placebo days they were higher 15 min after clemastine (p less th...
متن کاملEffect of an inhaled antihistamine (clemastine) as a bronchodilator and as a maintenance treatment in asthma.
Although intravenous chlorpheniramine can cause bronchodilatation, oral and parenteral antihistamines have not proved useful in treating asthma. Inhaled antihistamines may cause throat irritation, but a recent study of the antihistamine, clemastine, showed it to be an effective bronchodilator without irritant effects. We have extended these studies to determine the site of action of inhaled cle...
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ژورنال
عنوان ژورنال: Thorax
سال: 1978
ISSN: 0040-6376
DOI: 10.1136/thx.33.4.479